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Activated SIRT1 deacetylates PGC-1 resulting in increased transcriptional activity and thus, enhanced mitochondrial biogenesis

Sci Rep 2018, 8 (1), 7995

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Conclusion Melanosis coli is a common adverse effect of chronic laxative use which is more common in elderly population with constipation

Comprehensive medical assessment is essential before starting treatment, particularly if gallbladder removal was due to complications or if pancreatitis history exists